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Assessment of a FBXW8 frameshift mutation, c.1312_1313delGT, in breast cancer patients and controls from Central Europe.

Cancer genetics - 1 Jan 2018

Wang Jing, Bogdanova Natalia, Schürmann Peter, Park-Simon Tjoung-Won, Geffers Robert, Dörk Thilo

Abstract excerpt

F-box proteins participate in multiple cellular processes through ubiquitylation and subsequent degradation of target proteins, such as cyclin D1 as target of FBXW8. To investigate the spectrum of FBXW8 germ-line mutations in patients with breast cancer and healthy controls, we analyzed the whole FBXW8 coding region and flanking untranslated portions in germ-line DNA samples of 91 breast cancer patients and 277...

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PMID: 29310837
DOI: 10.1016/j.cancergen.2017.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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