Article
Genetic background influences cardiac phenotype in murine chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jul 2018
Neuburg Samantha, Dussold Corey, Gerber Claire, Wang Xueyan, Francis Connor, Qi Lixin, David Valentin, Wolf Myles, Martin Aline
Abstract excerpt
Background: Levels of fibroblast growth factor 23 (FGF23) increase early in chronic kidney disease (CKD) and are independently associated with left ventricular hypertrophy (LVH), heart failure and death. Experimental models of CKD with elevated FGF23 and LVH are needed. We hypothesized that slow rates of CKD progression in the Col4a3 knockout (Col4a3KO) mouse model of CKD would promote development of LVH by...
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