Article
S100/Calgranulin-mediated inflammation accelerates left ventricular hypertrophy and aortic valve sclerosis in chronic kidney disease in a receptor for advanced glycation end products-dependent manner.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2014
Yan Ling, Mathew Liby, Chellan Bijoy, Gardner Brandon, Earley Judy, Puri Tipu S, Hofmann Bowman Marion A
Abstract excerpt
OBJECTIVE: S100A12 and fibroblast growth factor 23 are biomarkers of cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). We tested the hypothesis that human S100/calgranulin would accelerate cardiovascular disease in mice subjected to CKD. APPROACH AND RESULTS: A bacterial artificial chromosome of the human S100/calgranulin gene cluster containing the genes and regulatory...
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