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Article

Fanconi anemia type C-deficient hematopoietic stem/progenitor cells exhibit aberrant cell cycle control.

Blood - 15 Sept 2003

Li Xiaxin, Plett P Artur, Yang Yanzhu, Hong Ping, Freie Brian, Srour Edward F, Orschell Christie M, Clapp D Wade, Haneline Laura S

Abstract excerpt

The pathogenesis of bone marrow failure in Fanconi anemia is poorly understood. Suggested mechanisms include enhanced apoptosis secondary to DNA damage and altered inhibitory cytokine signaling. Recent data determined that disrupted cell cycle control of hematopoietic stem and/or progenitor cells disrupts normal hematopoiesis with increased hematopoietic stem cell cycling resulting in diminished function and...

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Identifiers

PMID: 12763929
DOI: 10.1182/blood-2003-02-0536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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