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Article

Antibiotics Drive Expansion of Rare Pathogens in a Chronic Infection Microbiome Model

16 Aug 2022

Abstract excerpt

We develop and clinically benchmark an experimental model of the cystic fibrosis (CF) lung infection microbiome to investigate the impacts of antibiotic exposures on chronic, polymicrobial infections. We show that a single experimental model defined by metacommunity data can partially recapitulate the diversity of individual microbiome states observed across a population of people with CF. In the absence of...

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PMID: 35972133
DOI: 10.1128/msphere.00318-22

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