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Article

Mutations of perforin gene in Chinese patients with acute lymphoblastic leukemia.

Leukemia research - 1 Feb 2011

Yang Liyun, Liu Hongxing, Zhao Jun, Da Wanming, Zheng Jingchen, Wang Lixiang, Li Gong, Zhu Ping

Abstract excerpt

To address whether mutations and single nucleotide polymorphisms (SNPs) in perforin gene (PRF1) are correlated with acute lymphoblastic leukemia (ALL) in Chinese, we screened mutations in codon region of PRF1 in 111 ALL patients, and correlated the results with patients' immunophenotype, karyotype and fusion genes. Four novel monoallelic missense and two novel monoallelic synonymous mutations (G198R, R225Q,...

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Source

Identifiers

PMID: 20638125
DOI: 10.1016/j.leukres.2010.06.016

Genes

PRF1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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