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T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity

21 Mar 2023

Abstract excerpt

The recent revolution in tissue-resident macrophage biology has resulted largely from murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we analyze immune cells in the pleural cavity. Unlike C57BL/6 mice, naive tissue-resident large-cavity macrophages (LCMs) of BALB/c mice failed to fully implement the tissue-residency program. Following infection with a pleural-dwelling nematode,...

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PMID: 36948193
DOI: 10.1016/j.immuni.2023.02.016

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