Immune checkpoint-related serum proteins and genetic variants predict outcomes of localized prostate cancer, a cohort study.

doi:10.1007/s00262-020-02718-1

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Article

Immune checkpoint-related serum proteins and genetic variants predict outcomes of localized prostate cancer, a cohort study.

Cancer immunology, immunotherapy : CII - 1 Mar 2021

Wang Qinchuan, Ye Yuanqing, Yu Hao, Lin Shu-Hong, Tu Huakang, Liang Dong, Chang David W, Huang Maosheng, Wu Xifeng

Abstract excerpt

BACKGROUND: The clinical predictors and biological mechanisms for localized prostate cancer (PCa) outcomes remain mostly unknown. We aim to evaluate the role of serum immune-checkpoint-related (ICK) proteins and genetic variations in predicting outcomes of localized PCa. METHODS: We profiled the serum levels of 14 ICK-related proteins (BTLA, GITR, HVEM, IDO, LAG-3, PD-1, PD-L1, PD-L2, Tim-3, CD28, CD80, 4-1BB,...

Topics

Aged
Biomarkers
Cohort Studies
Disease Progression
Disease Susceptibility
Genetic Variation
Genotype
Humans
Immune Checkpoint Proteins
Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kaplan-Meier Estimate

Male

Middle Aged

Neoplasm Staging

Prognosis

Prostatic Neoplasms

Receptors, Antigen, B-Cell

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Identifiers

PMID: 32909077
DOI: 10.1007/s00262-020-02718-1
PMCID: PMC7907032

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