Article
The effect of cisplatin on cytotoxicity of anticancer cytokine TRAIL and its receptor-selective mutant variant DR5-B1.
Doklady. Biochemistry and biophysics - 1 Nov 2017
Gasparian M E, Bychkov M L, Yagolovich A V, Kirpichnikov M P, Dolgikh D A
Abstract excerpt
Cytokine TRAIL selectively induces apoptosis in vitro and in vivo in tumor cells without affecting normal cells, but its therapeutic application is limited, since many primary tumors are insensitive to TRAIL. To improve the efficiency of TRAIL, we have previously developed TRAIL mutant variant DR5-B, which binds the apoptosis-inducing death receptor DR5 as efficiently as wild type TRAIL, but shows almost no...
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