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Article

Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole.

Oncogene - 29 May 2008

Goda A E, Yoshida T, Horinaka M, Yasuda T, Shiraishi T, Wakada M, Sakai T

Abstract excerpt

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as an attractive cytokine that selectively targets cancer cells, however its efficacy has been challenged by a number of resistance mechanisms. Therefore, the current study investigated the potential of dipyridamole to enhance TRAIL efficacy and the probable underlying mechanisms. Dipyridamole dramatically sensitized p53-mutant human...

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PMID: 18193086
DOI: 10.1038/sj.onc.1211008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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