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Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease

1 Jul 2019

Abstract excerpt

Down syndrome (DS) is a well-known neurodevelopmental disorder most commonly caused by trisomy of chromosome 21. Because individuals with DS almost universally develop heavy amyloid burden and Alzheimer's disease (AD), biomarker discovery in this population may be extremely fruitful. Moreover, any AD biomarker in DS that does not directly involve amyloid pathology may be of high value for understanding broader...

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PMID: 31419370
DOI: 10.1002/dneu.22716

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