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Article

Clinical response to PD-1 blockade correlates with a sub-fraction of peripheral central memory CD4+ T cells in patients with malignant melanoma.

International immunology - 3 Feb 2018

Takeuchi Yoshiko, Tanemura Atsushi, Tada Yasuko, Katayama Ichiro, Kumanogoh Atsushi, Nishikawa Hiroyoshi

Abstract excerpt

Cancer immunotherapy that blocks immune checkpoint molecules, such as PD-1/PD-L1, unleashes dysfunctional antitumor T-cell responses and has durable clinical benefits in various types of cancers. Yet its clinical efficacy is limited to a small proportion of patients, highlighting the need for identifying biomarkers that can predict the clinical response by exploring antitumor responses crucial for tumor...

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Share to Antibodies, Monoclonal, Humanized
Share to Antineoplastic Agents, Immunological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

Share to CD4-Positive T-Lymphocytes

Share to Melanoma

Share to Nivolumab

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Share to Programmed Cell Death 1 Receptor

Source

Identifiers

PMID: 29294043
DOI: 10.1093/intimm/dxx073

Genes

CCR7
FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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