Article
Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma.
The Journal of clinical investigation - 1 Sept 2016
Daud Adil I, Loo Kimberly, Pauli Mariela L, Sanchez-Rodriguez Robert, Sandoval Priscila Munoz, Taravati Keyon, Tsai Katy, Nosrati Adi, Nardo Lorenzo, Alvarado Michael D, Algazi Alain P, Pampaloni Miguel H, Lobach Iryna V, Hwang Jimmy, Pierce Robert H, Gratz Iris K, Krummel Matthew F, Rosenblum Michael D
Abstract excerpt
BACKGROUND: Immune checkpoint blockade is revolutionizing therapy for advanced cancer, but many patients do not respond to treatment. The identification of robust biomarkers that predict clinical response to specific checkpoint inhibitors is critical in order to stratify patients and to rationally select combinations in the context of an expanding array of therapeutic options. METHODS: We performed multiparameter...
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