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Article

Next-Generation Sequencing and Result Interpretation in Clinical Oncology: Challenges of Personalized Cancer Therapy.

Annual review of medicine - 14 Jan 2017

Khotskaya Yekaterina B, Mills Gordon B, Mills Shaw Kenna R

Abstract excerpt

The tools of next-generation sequencing (NGS) technology, such as targeted sequencing of candidate cancer genes and whole-exome and -genome sequencing, coupled with encouraging clinical results based on the use of targeted therapeutics and biomarker-guided clinical trials, are fueling further technological advancements of NGS technology. However, NGS data interpretation is associated with challenges that must be...

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PMID: 27813876
DOI: 10.1146/annurev-med-102115-021556

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