Article
Personalized genomic analyses for cancer mutation discovery and interpretation.
Science translational medicine - 15 Apr 2015
Jones Siân, Anagnostou Valsamo, Lytle Karli, Parpart-Li Sonya, Nesselbush Monica, Riley David R, Shukla Manish, Chesnick Bryan, Kadan Maura, Papp Eniko, Galens Kevin G, Murphy Derek, Zhang Theresa, Kann Lisa, Sausen Mark, Angiuoli Samuel V, Diaz Luis A, Velculescu Victor E
Abstract excerpt
Massively parallel sequencing approaches are beginning to be used clinically to characterize individual patient tumors and to select therapies based on the identified mutations. A major question in these analyses is the extent to which these methods identify clinically actionable alterations and whether the examination of the tumor tissue alone is sufficient or whether matched normal DNA should also be analyzed...
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