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Effects of individual amino acid mutations of zinc transporter ZIP8 on manganese- and cadmium-transporting activity.

Biochemical and biophysical research communications - 6 Aug 2022

Fujishiro Hitomi, Miyamoto Sara, Sumi Daigo, Kambe Taiho, Himeno Seiichiro

Abstract excerpt

Zinc (Zn) transporter ZIP8, encoded by SLC39A8, is a unique transporter that can transport divalent manganese (Mn) and cadmium (Cd) in addition to Zn. Recently, associations between various human diseases and variant forms of ZIP8 have been reported. Four amino acid residues, V33, G38, S335, and I340, of human ZIP8 (hZIP8) are mutated in patients with congenital disorders of glycosylation (CDG), whose blood Mn...

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PMID: 35636252
DOI: 10.1016/j.bbrc.2022.05.068

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