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Article

Sequencing of Linkage Region on Chromosome 12p11 Identifies PKP2 as a Candidate Gene for Left Ventricular Mass in Dominican Families.

G3 (Bethesda, Md.) - 2 Feb 2018

Dueker Nicole D, Guo Shengru, Beecham Ashley, Wang Liyong, Blanton Susan H, Di Tullio Marco R, Rundek Tatjana, Sacco Ralph L

Abstract excerpt

Increased left ventricular mass (LVM) is an intermediate phenotype for cardiovascular disease (CVD) and a predictor of stroke. Using families from the Dominican Republic, we have previously shown LVM to be heritable and found evidence for linkage to chromosome 12p11. Our current study aimed to further characterize the QTL by sequencing the 1 LOD unit down region in 10 families from the Dominican Republic with...

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Topics

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Share to Chromosomes, Human, Pair 12
Share to Family Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Linkage

Share to Hypertrophy, Left Ventricular

Share to Plakophilins

Share to Polymorphism, Single Nucleotide

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 29288195
DOI: 10.1534/g3.117.300358
PMCID: PMC5919734

Genes

PKP2
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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