A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy.

doi:10.1186/s12920-018-0339-9

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Article

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy.

BMC medical genomics - 5 Mar 2018

Silva Claudia Tamar, Zorkoltseva Irina V, Niemeijer Maartje N, van den Berg Marten E, Amin Najaf, Demirkan Ayşe, van Leeuwen Elisa, Iglesias Adriana I, Piñeros-Hernández Laura B, Restrepo Carlos M, Kors Jan A, Kirichenko Anatoly V, Willemsen Rob, Oostra Ben A, Stricker Bruno H, Uitterlinden André G, Axenovich Tatiana I, van Duijn Cornelia M, Isaacs Aaron

Abstract excerpt

BACKGROUND: Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two principal components derived from them. METHODS: The study was conducted among participants from the Erasmus Rucphen Family Study (ERF), a Dutch family-based sample...

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PMID: 29506515
DOI: 10.1186/s12920-018-0339-9
PMCID: PMC5838853

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