Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.

doi:10.1371/journal.pone.0189730

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Article

Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.

PloS one - 1 Jan 2017

Yin Fei, Xie Ying, Fan Haiyan, Zhang Jingjing, Guo Zhanjun

Abstract excerpt

Proofreading deficiencies of hepatitis B virus polymerase result in frequent DNA mutations in the hepatitis B virus genome. Here, we performed sequencing analysis of the hepatitis B virus polymerase gene to assess its association with the postoperative survival in 92 patients with HBV-related hepatocellular carcinoma by using the Kaplan-Meier method. The 2525, 2733, 2738, 2768, 2946, 3063, 3066, 3109, 31, 529,...

Topics

Carcinoma, Hepatocellular
DNA-Directed DNA Polymerase
Female
Hepatitis B
Hepatitis B virus
Humans
Liver Neoplasms
Male
Middle Aged
Mutation
Postoperative Period
Real-Time Polymerase Chain Reaction
Survival Analysis

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Identifiers

PMID: 29287068
DOI: 10.1371/journal.pone.0189730
PMCID: PMC5747429

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