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Article

Inner tegument proteins of Herpes Simplex Virus are sufficient for intracellular capsid motility in neurons but not for axonal targeting.

PLoS pathogens - 1 Dec 2017

Buch Anna, Müller Oliver, Ivanova Lyudmila, Döhner Katinka, Bialy Dagmara, Bosse Jens B, Pohlmann Anja, Binz Anne, Hegemann Maike, Nagel Claus-Henning, Koltzenburg Martin, Viejo-Borbolla Abel, Rosenhahn Bodo, Bauerfeind Rudolf, Sodeik Beate

Abstract excerpt

Upon reactivation from latency and during lytic infections in neurons, alphaherpesviruses assemble cytosolic capsids, capsids associated with enveloping membranes, and transport vesicles harboring fully enveloped capsids. It is debated whether capsid envelopment of herpes simplex virus (HSV) is completed in the soma prior to axonal targeting or later, and whether the mechanisms are the same in neurons derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29284065
DOI: 10.1371/journal.ppat.1006813
PMCID: PMC5761964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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