Article
Herpes simplex virus gE/gI extracellular domains promote axonal transport and spread from neurons to epithelial cells.
Journal of virology - 1 Oct 2014
Howard Paul W, Wright Catherine C, Howard Tiffani, Johnson David C
Abstract excerpt
UNLABELLED: Following reactivation from latency, there are two distinct steps in the spread of herpes simplex virus (HSV) from infected neurons to epithelial cells: (i) anterograde axonal transport of virus particles from neuron bodies to axon tips and (ii) exocytosis and spread of extracellular virions across cell junctions into adjacent epithelial cells. The HSV heterodimeric glycoprotein gE/gI is important for...
Topics
- Animals
- Axonal Transport
- Capsid
- Cell Line
- Chlorocebus aethiops
- Embryo, Mammalian
- Gene Expression Regulation, Viral
- Humans
- Intercellular Junctions
- Keratinocytes
- Mutation
- Neurons
- Protein Multimerization
- Protein Structure, Tertiary