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Article

The Apical Region of the Herpes Simplex Virus Major Capsid Protein Promotes Capsid Maturation.

Journal of virology - 15 Sept 2018

Ruhge Laura L, Huet Alexis G E, Conway James F, Smith Gregory A

Abstract excerpt

The herpesvirus capsid assembles in the nucleus as an immature procapsid precursor built around viral scaffold proteins. The event that initiates procapsid maturation is unknown, but it is dependent upon activation of the VP24 internal protease. Scaffold cleavage triggers angularization of the shell and its decoration with the VP26 and pUL25 capsid-surface proteins. In both the procapsid and mature angularized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29976665
DOI: 10.1128/JVI.00821-18
PMCID: PMC6146679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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