Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.

Science translational medicine - 3 Dec 2014

Hill James M, Quenelle Debra C, Cardin Rhonda D, Vogel Jodi L, Clement Christian, Bravo Fernando J, Foster Timothy P, Bosch-Marce Marta, Raja Priya, Lee Jennifer S, Bernstein David I, Krause Philip R, Knipe David M, Kristie Thomas M

Abstract excerpt

Herpesviruses are highly prevalent and maintain lifelong latent reservoirs, thus posing challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals that target viral DNA replication. The initiation of herpes simplex virus infection and reactivation from latency is dependent on a transcriptional coactivator complex that contains two required histone demethylases, LSD1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Guinea Pigs
Share to Herpesviridae Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Demethylases

Share to Oxidoreductases, N-Demethylating

Share to Vagina

Share to Virus Activation

Share to Virus Latency

Share to Virus Shedding

Source

Open in PubMed Open full text

Identifiers

PMID: 25473037
DOI: 10.1126/scitranslmed.3010643
PMCID: PMC4416407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.PMID 25473037Read ↗

Targeting the JMJD2 Histone Demethylases to Epigenetically Control Herpesvirus Infection and Reactivation from LatencySemantic proximity Read ↗

A Novel Selective LSD1/KDM1A Inhibitor Epigenetically Blocks Herpes Simplex Virus Lytic Replication and Reactivation from LatencySemantic proximity Read ↗

Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency.Semantic proximity Read ↗

Clinical management of herpes simplex virus infections: past, present, and futureSemantic proximity Read ↗

Ex Vivo Herpes Simplex Virus Reactivation Involves a Dual Leucine Zipper Kinase-Dependent Wave of Lytic Gene Expression That Is Independent of Histone Demethylase Activity and Viral Genome SynthesisSemantic proximity Read ↗

Epigenetically repressing human cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylasesSemantic proximity Read ↗

Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylationSemantic proximity Read ↗

Gene editing for latent herpes simplex virus infection reduces viral load and shedding in vivoSemantic proximity Read ↗

Ocular Herpes Simplex Virus: How are Latency, Reactivation, Recurrent Disease and Therapy Interrelated?Semantic proximity Read ↗

AAV-delivered gene editing for latent genital or orofacial herpes simplex virus infection reduces ganglionic viral load and minimizes subsequent viral shedding in miceSemantic proximity Read ↗

Trimethylation of Histone H3 Lysine 4 by Set1 in the Lytic Infection of Human Herpes Simplex Virus 1Semantic proximity Read ↗

Control of viral infections by epigenetic-targeted therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.