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N 6 -methyladenosine is required for efficient RNA synthesis of Ebola virus and other haemorrhagic fever viruses

12 Jun 2023

Abstract excerpt

N6-methyladenosine (m6A) is one of the most abundant modifications of cellular RNA, where it serves various functions. m6A methylation of many viral RNA species has also been described; however, little is known about the m6A epitranscriptome of haemorrhagic fever-causing viruses like Ebola virus (EBOV). Here, we analysed the importance of the methyltransferase METTL3 for the life cycle of this virus. We found...

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PMID: 37306620
DOI: 10.1080/22221751.2023.2223732

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