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Article

Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain.

Protein science : a publication of the Protein Society - 1 Mar 2018

Scaglione Antonella, Monteonofrio Laura, Parisi Giacomo, Cecchetti Cristina, Siepi Francesca, Rinaldo Cinzia, Giorgi Alessandra, Verzili Daniela, Zamparelli Carlotta, Savino Carmelinda, Soddu Silvia, Vallone Beatrice, Montemiglio Linda Celeste

Abstract excerpt

The dual-specificity activity of the homeodomain interacting protein kinase 2 (HIPK2) is regulated by cis-auto-phosphorylation of tyrosine 361 (Y361) on the activation loop. Inhibition of this process or substitution of Y361 with nonphosphorylatable amino acid residues result in aberrant HIPK2 forms that show altered functionalities, pathological-like cellular relocalization, and accumulation into cytoplasmic...

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Identifiers

PMID: 29277937
DOI: 10.1002/pro.3367
PMCID: PMC5818748

Genes

HIPK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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