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Article

Sphingosine Induces Apoptosis and Down-regulation of MYCN in PAX3-FOXO1-positive Alveolar Rhabdomyosarcoma Cells Irrespective of TP53 Mutation.

Anticancer research - 1 Jan 2018

Ahn Eun Hyun, Lee Michael B, Seo Dong Joo, Lee Juseong, Kim Yonghyun, Gupta Kshitiz

Abstract excerpt

BACKGROUND/AIM: Rhabdomyosarcoma is the most common type of pediatric soft-tissue sarcoma. Among the subsets of this disease, alveolar rhabdomyosarcoma (ARMS) expressing paired box 3 (PAX3) and forkhead box O1 (PAX3-FOXO1) fusion oncoprotein has the worst prognosis. The goal of this study was to investigate the chemotherapeutic effects of sphingosine on PAX3-FOXO1-positive ARMS cells [tumor protein p53...

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Identifiers

PMID: 29277758
DOI: 10.21873/anticanres.12193

Genes

MYCN
PAX3
FOXO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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