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Article

FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation.

Cell death & disease - 31 Aug 2017

Pirou Caroline, Montazer-Torbati Fatemeh, Jah Nadège, Delmas Elisabeth, Lasbleiz Christelle, Mignotte Bernard, Renaud Flore

Abstract excerpt

Neuroblastoma, a sympathetic nervous system tumor, accounts for 15% of cancer deaths in children. In contrast to most human tumors, p53 is rarely mutated in human primary neuroblastoma, suggesting impaired p53 activation in neuroblastoma. Various studies have shown correlations between fgf1 expression levels and both prognosis severity and tumor chemoresistance. As we previously showed that fibroblast growth...

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Identifiers

PMID: 29048426
DOI: 10.1038/cddis.2017.404
PMCID: PMC5596585

Genes

FGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation.PMID 29048426Read ↗

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