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Synthetic phosphoethanolamine has in vitro and in vivo anti-leukemia effects

1 Nov 2013

Abstract excerpt

BACKGROUND: We recently showed that synthetic phosphoethanolamine reduces tumour growth and inhibits lung metastasis in vivo. Here, we investigated its anti-leukaemia effects using acute promyelocytic leukaemia (APL) as a model. METHODS: Cytotoxic effects of Pho-s on leukaemia cells were evaluated by MTT assay. Leukaemic cells obtained from hCG-PML-RARa transgenic mice were transplanted to NOD/SCID mice. After...

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PMID: 24201752
DOI: 10.1038/bjc.2013.510

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