Article

The ITGA6-AEBP2 Complex Promotes Transcriptional Activation of GSK3β to Augment Wntβ-Catenin Signaling and Stemness in Pancreatic Cancer

2026-03-10

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Pancreatic cancer (PC) remains one of the most lethal malignancies in the digestive system, posing a significant threat to human health due to the critical lack of therapeutic targets. While integrin α6 (ITGA6) has been implicated as a key regulator in multiple cancer types, its precise functional role and molecular mechanisms in pancreatic tumorigenesis remai...

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Literature Corpus work: af016f69-a65d-5a7d-a8ef-4fb42a8a3b44
DOI: 10.21203/rs.3.rs-8683090/v1

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