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Article

Influence of solubilization and AD-mutations on stability and structure of human presenilins.

Scientific reports - 21 Dec 2017

Yang Ge, Yu Kun, Kaitatzi Christina-Symina, Singh Abhilasha, Labahn Jörg

Abstract excerpt

Presenilin (PS1 or PS2) functions as the catalytic subunit of γ-secretase, which produces the toxic amyloid beta peptides in Alzheimer's disease (AD). The dependence of folding and structural stability of PSs on the lipophilic environment and mutation were investigated by far UV CD spectroscopy. The secondary structure content and stability of PS2 depended on the lipophilic environment. PS2 undergoes a...

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Identifiers

PMID: 29269939
DOI: 10.1038/s41598-017-18313-x
PMCID: PMC5740079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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