Article
Effects of a cannabinoid receptor (CB) 1 antagonist AM251 on behavioral sensitization to nicotine in a rat model of novelty-seeking behavior: correlation with hippocampal 5HT.
Psychopharmacology - 1 Mar 2009
Bhatti Amrinder S, Aydin Cigdem, Oztan Ozge, Ma Zhiyuan, Hall Penny, Tao Rui, Isgor Ceylan
Abstract excerpt
RATIONALE: There are marked individual differences in the efficacy of mainstream nicotine cessation agents in preventing relapse. A rat model of novelty-seeking phenotype was reported to have predictive value for psychostimulant taking behavior where locomotor reactivity to novelty is used to rank high (HR, highest 1/3) versus low (LR, lowest 1/3) responsiveness to novelty in outbred rats. We tested the...
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