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Workflow optimization of whole genome amplification and targeted panel sequencing for CTC mutation detection

24 Oct 2017

Abstract excerpt

Genomic characterization of circulating tumor cells (CTCs) may prove useful as a surrogate for conventional tissue biopsies. This is particularly important as studies have shown different mutational profiles between CTCs and ctDNA in some tumor subtypes. However, isolating rare CTCs from whole blood has significant hurdles. Very limited DNA quantities often can't meet NGS requirements without whole genome...

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PMID: 29263843
DOI: 10.1038/s41525-017-0034-3

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