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Next-generation Sequencing (NGS) Analysis on Single Circulating Tumor Cells (CTCs) with No Need of Whole-genome Amplification (WGA).

Cancer genomics & proteomics - 1 Jan 2000

Palmirotta Raffaele, Lovero Domenica, Silvestris Erica, Felici Claudia, Quaresmini Davide, Cafforio Paola, Silvestris Franco

Abstract excerpt

BACKGROUND: Isolation and genotyping of circulating tumor cells (CTCs) is gaining an increasing interest by clinical researchers in oncology not only for investigative purposes, but also for concrete application in clinical practice in terms of diagnosis, prognosis and decision treatment with targeted therapies. For the mutational analysis of single CTCs, the most advanced biotechnology methodology currently...

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Biomarkers, Tumor
Cancer Cells and Metastasis
Genotype
High-Throughput Nucleotide Sequencing
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplastic Cells, Circulating

Single-Cell Analysis

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Identifiers

PMID: 28446532
DOI: 10.21873/cgp.20029
PMCID: PMC5420818

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