Article
RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions.
The Journal of experimental medicine - 2 Jan 2018
Hogstad Brandon, Berres Marie-Luise, Chakraborty Rikhia, Tang Jun, Bigenwald Camille, Serasinghe Madhavika, Lim Karen Phaik Har, Lin Howard, Man Tsz-Kwong, Remark Romain, Baxter Samantha, Kana Veronika, Jordan Stefan, Karoulia Zoi, Kwan Wing-Hong, Leboeuf Marylene, Brandt Elisa, Salmon Helene, McClain Kenneth, Poulikakos Poulikos, Chipuk Jerry, Mulder Willem J M, Allen Carl E, Merad Miriam
Abstract excerpt
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately 60% of LCH patients harbor somatic BRAFV600E mutations localizing to CD207+ DCs within lesions. However, the mechanisms driving BRAFV600E+ LCH cell...
Topics
- Animals
- Apoptosis
- Cell Movement
- Dendritic Cells
- Histiocytosis, Langerhans-Cell
- Humans
- Langerhans Cells
- MAP Kinase Signaling System