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Sperm dysfunction and ciliopathy

14 Oct 2015

Abstract excerpt

Sperm motility is driven by motile cytoskeletal elements in the tail, called axonemes. The structure of axonemes consists of 9 + 2 microtubules, molecular motors (dyneins), and their regulatory structures. Axonemes are well conserved in motile cilia and flagella through eukaryotic evolution. Deficiency in the axonemal structure causes defects in sperm motility, and often leads to male infertility. It has been...

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PMID: 29259424
DOI: 10.1007/s12522-015-0225-5

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