No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes.

doi:10.1038/s41598-017-17664-9

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Article

No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes.

Scientific reports - 19 Dec 2017

Swann O V, Harrison E M, Opi D H, Nyatichi E, Macharia A, Uyoga S, Williams T N, Rowe J A

Abstract excerpt

Clustering of Complement Receptor 1 (CR1) in the erythrocyte membrane is important for immune-complex transfer and clearance. CR1 contains the Knops blood group antigens, including the antithetical pairs Swain-Langley 1 and 2 (Sl1 and Sl2) and McCoy a and b (McCa and McCb), whose functional effects are unknown. We tested the hypothesis that the Sl and McC polymorphisms might influence CR1 clustering on...

Topics

Blood Group Antigens
Child
Cluster Analysis
Erythrocyte Membrane
Erythrocytes
Female
Gene Dosage
Genotype
Humans
Kenya
Male
Polymorphism, Genetic
Receptors, Complement 3b

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Identifiers

PMID: 29259218
DOI: 10.1038/s41598-017-17664-9
PMCID: PMC5736761

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