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Article

Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria.

PloS one - 1 Jan 2012

Tetteh-Quarcoo Patience B, Schmidt Christoph Q, Tham Wai-Hong, Hauhart Richard, Mertens Haydyn D T, Rowe Arthur, Atkinson John P, Cowman Alan F, Rowe J Alexandra, Barlow Paul N

Abstract excerpt

Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected erythrocytes. The non-uniform geographical distribution of Knops blood group CR1 alleles Sl1/2 and McC(a/b) may result from selective pressures exerted by differential...

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Identifiers

PMID: 22506052
DOI: 10.1371/journal.pone.0034820
PMCID: PMC3323580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria.PMID 22506052Read ↗

Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1Semantic proximity Read ↗

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No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes.Semantic proximity Read ↗

Reduced Immune Complex Binding Capacity and Increased Complement Susceptibility of Red Cells from Children with Severe Malaria-Associated AnemiaSemantic proximity Read ↗

Role of CR1 Knops polymorphism in the pathophysiology of malaria: Indian scenario.Semantic proximity Read ↗

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CR1 levels and gene polymorphisms exhibit differential association with falciparum malaria in regions of varying disease endemicity.Semantic proximity Read ↗

Complement Receptor 1 availability on red blood cell surface modulates Plasmodium vivax invasion of human reticulocytesSemantic proximity Read ↗

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Human complement receptor type 1 (CR1) binds to a major malarial adhesinSemantic proximity Read ↗

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