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Article

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

24 Apr 2018

Abstract excerpt

Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McCb, occur at high frequencies, consistent with selection by malaria. Previous studies have been inconclusive. Using a large case-control study of severe malaria in Kenyan children and statistical models adjusted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29690995
DOI: 10.7554/elife.31579

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