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Article

Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease.

BMC genomics - 20 Dec 2014

Krishna Abhimanyu, Biryukov Maria, Trefois Christophe, Antony Paul M A, Hussong Rene, Lin Jake, Heinäniemi Merja, Glusman Gustavo, Köglsberger Sandra, Boyd Olga, van den Berg Bart H J, Linke Dennis, Huang David, Wang Kai, Hood Leroy, Tholey Andreas, Schneider Reinhard, Galas David J, Balling Rudi, May Patrick

Abstract excerpt

BACKGROUND: The human neuroblastoma cell line, SH-SY5Y, is a commonly used cell line in studies related to neurotoxicity, oxidative stress, and neurodegenerative diseases. Although this cell line is often used as a cellular model for Parkinson's disease, the relevance of this cellular model in the context of Parkinson's disease (PD) and other neurodegenerative diseases has not yet been systematically evaluated....

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Identifiers

PMID: 25528190
DOI: 10.1186/1471-2164-15-1154
PMCID: PMC4367834

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