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Article

Impact of donor and recipient CYP3A5 and ABCB1 genetic polymorphisms on tacrolimus dosage requirements and rejection in Caucasian Spanish liver transplant patients.

Journal of clinical pharmacology - 1 Nov 2013

Gómez-Bravo Miguel Angel, Salcedo Magdalena, Fondevila Constantino, Suarez Francisco, Castellote José, Rufian Sebastián, Pons José Antonio, Alamo José María, Millán Olga, Brunet Mercè

Abstract excerpt

Studies of liver transplant (LT) patients, mainly in Asians, have evaluated the influence of the CYP3A5*1 allele and P-glycoprotein gene ABCB1 on tacrolimus pharmacokinetics or biopsy-proven acute rejection (BPAR) incidence, with no conclusive results. To investigate these issues, 98 Caucasian Spanish LT patients with tacrolimus, mycophenolate mofetil and steroids and 88 cadaveric donors were genotyped for the...

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Identifiers

PMID: 23900887
DOI: 10.1002/jcph.154

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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