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Article

CYP3A53 and CYP2C83 variants influence exposure and clinical outcomes of tacrolimus-based therapy.

Pharmacogenomics - 1 Jan 2020

Genvigir Fabiana Dalla Vecchia, Campos-Salazar Antony Brayan, Felipe Claudia Rosso, Tedesco-Silva Helio, Medina-Pestana José Osmar, Doi Sonia de Quateli, Cerda Alvaro, Hirata Mario Hiroyuki, Herrero María José, Aliño Salvador Francisco, Hirata Rosario Dominguez Crespo

Abstract excerpt

Aim: The influence of variants in pharmacokinetics-related genes on long-term exposure to tacrolimus (TAC)-based therapy and clinical outcomes was investigated. Patients & methods: Brazilian kidney recipients were treated with TAC combined with everolimus (n = 178) or mycophenolate sodium (n = 97). The variants in CYP2C8, CYP2J2, CYP3A4, CYP3A5, POR, ABCB1, ABCC2, ABCG2, SLCO1B1 and SLCO2B1 were analyzed. Main...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31849280
DOI: 10.2217/pgs-2019-0120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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