Article
The association between APOA1 (rs5069) gene polymorphism and insulin resistance surrogates and metabolic indices among obese individuals with different glycemic statuses (euglycemic and T2DM).
Scientific reports - 20 Dec 2025
Usama Nagla, Ahmed Amr E, Mekheimer Salma, Elhadidy Khaled, Farid Mahmoud
Abstract excerpt
Obesity significantly contributes to insulin resistance and type 2 mellitus diabetes (T2DM), with both environmental and genetic factors influencing metabolic risk. Apolipoprotein A1 (APOA1), a key regulator of lipid metabolism, has genetic variants such as rs5069 that may affect metabolic profiles. This study investigated the association between APOA1 (rs5069) polymorphism and metabolic risk among euglycemic and...
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