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Article

Therapeutic dosing of acenocoumarol: proposal of a population specific pharmacogenetic dosing algorithm and its validation in north Indians.

PloS one - 1 Jan 2012

Rathore Saurabh Singh, Agarwal Surendra Kumar, Pande Shantanu, Singh Sushil Kumar, Mittal Tulika, Mittal Balraj

Abstract excerpt

OBJECTIVES: To develop a population specific pharmacogenetic acenocoumarol dosing algorithm for north Indian patients and show its efficiency in dosage prediction. METHODS: Multiple and linear stepwise regression analyses were used to include age, sex, height, weight, body surface area, smoking status, VKORC1 -1639 G>A, CYP4F2 1347 G>A, CYP2C9*2,*3 and GGCX 12970 C>G polymorphisms as variables to generate dosing...

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Source

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Identifiers

PMID: 22629463
DOI: 10.1371/journal.pone.0037844
PMCID: PMC3358293

Genes

VKORC1
GGCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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