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Sirtuins Expression and Their Role in Retinal Diseases

1 Jan 2017

Abstract excerpt

Sirtuins have received considerable attention since the discovery that silent information regulator 2 (Sir2) extends the lifespan of yeast. Sir2, a nicotinamide adenine dinucleotide- (NAD-) dependent histone deacetylase, serves as both a transcriptional effector and energy sensor. Oxidative stress and apoptosis are implicated in the pathogenesis of neurodegenerative eye diseases. Sirtuins confer protection...

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PMID: 28197299
DOI: 10.1155/2017/3187594

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