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Article

Sirt1: A Guardian of the Development of Diabetic Retinopathy

8 Jan 2018

Abstract excerpt

Diabetic retinopathy is a multifactorial disease, and the exact mechanism of its pathogenesis remains obscure. Sirtuin 1 (Sirt1), a multifunctional deacetylase, is implicated in the regulation of many cellular functions and in gene transcription, and retinal Sirt1 is inhibited in diabetes. Our aim was to determine the role of Sirt1 in the development of diabetic retinopathy and to elucidate the molecular...

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PMID: 29311218
DOI: 10.2337/db17-0996

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