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Article

Inhibition of HDAC2 Protects the Retina From Ischemic Injury

22 May 2013

Abstract excerpt

PURPOSE: Protein acetylation is an essential mechanism in regulating transcriptional and inflammatory events. Studies have shown that nonselective histone deacetylase (HDAC) inhibitors can protect the retina from ischemic injury in rats. However, the role of specific HDAC isoforms in retinal degenerative processes remains obscure. The purpose of this study was to investigate the role of HDAC2 isoform in a mouse...

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Share to Histone Deacetylase Inhibitors Research
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PMID: 23696608
DOI: 10.1167/iovs.12-11529

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