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Article

Co-expression Patterns between ATN1 and ATXN2 Coincide with Brain Regions Affected in Huntington’s Disease

30 Nov 2017

Abstract excerpt

CAG Repeat expansions in the coding regions of nine polyglutamine (polyQ) genes (HTT, ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, ATN1, AR, and TBP) are the cause of several neurodegenerative diseases including Huntington's disease (HD), six different spinocerebellar ataxias (SCAs), dentatorubral-pallidoluysian atrophy and spinobulbar muscular atrophy. The expanded CAG repeat length in the causative gene is negatively...

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PMID: 29249939
DOI: 10.3389/fnmol.2017.00399

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