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Article

Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2.

Human molecular genetics - 15 Aug 2017

Pflieger Lance T, Dansithong Warunee, Paul Sharan, Scoles Daniel R, Figueroa Karla P, Meera Pratap, Otis Thomas S, Facelli Julio C, Pulst Stefan M

Abstract excerpt

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease caused by CAG repeat expansion in the ATXN2 gene. The repeat resides in an encoded region of the gene resulting in polyglutamine (polyQ) expansion which has been assumed to result in gain of function, predominantly, for the ATXN2 protein. We evaluated temporal cerebellar expression profiles by RNA sequencing of ATXN2Q127 mice...

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Identifiers

PMID: 28525545
DOI: 10.1093/hmg/ddx191
PMCID: PMC5886232

Genes

ATXN2

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