Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vascular and dopaminergic contributors to mild parkinsonian signs in older adults.

Neurology - 16 Jan 2018

Rosso Andrea L, Bohnen Nicolaas I, Launer Lenore J, Aizenstein Howard J, Yaffe Kristine, Rosano Caterina

Abstract excerpt

OBJECTIVE: Mild parkinsonian signs (MPS) are an underappreciated neurologic condition in older adults; we assessed associations of MPS with measures of dopaminergic (catechol-O-methyltransferase [COMT] genotype, an indicator of synaptic dopamine levels) and vascular (white matter hyperintensities [WMH], an indicator of cerebral small vessel disease) factors. METHODS: In a cohort of older adults (mean age 82.6...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Sectional Studies

Share to Magnetic Resonance Imaging

Share to Organ Size

Share to Parkinsonian Disorders

Share to Severity of Illness Index

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 29247072
DOI: 10.1212/WNL.0000000000004842
PMCID: PMC5772161

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vascular and dopaminergic contributors to mild parkinsonian signs in older adults.PMID 29247072Read ↗

Comorbidity of white matter lesions in parkinson's disease: a study on risk factors and phenotypic differences.Semantic proximity Read ↗

Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s DiseaseSemantic proximity Read ↗

Cerebral small vessel disease may not critically influence familial Parkinson’s diseaseSemantic proximity Read ↗

Association among Parkinsonism-related motor complaints, cerebral small vessel disease, and cerebrovascular risk factors in a community-dwelling populationSemantic proximity Read ↗

Mild Behavioral Impairment in Parkinson's Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects.Semantic proximity Read ↗

Vascular Phenotyping in Parkinson’s Disease: Diabetes Mellitus Operationalizes a Microvascular Metabolic Syndrome Cluster Across PPMI Diagnostic CohortsSemantic proximity Read ↗

Does<i>COMT</i>Play a Role in Parkinson’s Disease Susceptibility Across Diverse Ancestral Populations?Semantic proximity Read ↗

Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease.Semantic proximity Read ↗

Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease.Semantic proximity Read ↗

Associations of Vascular Risk Factors and APOE Genotype With Perivascular Spaces Among Community-Dwelling Older Adults.Semantic proximity Read ↗

APOE, MAPT, and COMT and Parkinson's Disease Susceptibility and Cognitive Symptom Progression.Semantic proximity Read ↗

Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.