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Article

Exploring cerebral small vessel disease signatures in familial Parkinson's disease.

Scientific reports - 8 Sept 2026

Mahat Bigyan, Malla Bimala, Foddis Marco, Beule Dieter, Bras Jose, Guerreiro Rita, Kola Vasilis, Schmitt Hans-Michael, Endres Matthias, Sassi Celeste

Abstract excerpt

Familial Parkinson's disease (PD) and vascular parkinsonism (VP) present overlapping features and may co-exist. To investigate whether PD and VP may share a potential pathogenic link and to what extent white matter hyperintensities may influence PD phenotype, we used the modified Scheltens scale and presented a descriptive and exploratory analysis of the classic neuroradiological features of cerebral small vessel...

Read the complete abstract on PubMed

Topics

Humans
Cerebral Small Vessel Diseases
Parkinson Disease
Female
Male
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Magnetic Resonance Imaging

Middle Aged

Genetic Predisposition to Disease

Exome Sequencing

White Matter

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Source

Open in PubMed Open full text

Identifiers

PMID: 42706363
DOI: 10.1038/s41598-026-69989-z
PMCID: PMC13550550

Genes

SNCA
ATP13A2
LAMP3
MAPT
PINK1
PRKN
STK39
VPS35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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